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Our group have demonstrated in previous studies [20] that the presence of steatosis showed some correspondence with the increase of superoxide anion generation in plump women galleries the animals fed a choline-deficient diet. Although some limitations of lucigenin-amplified chemiluminescence have been recently described, because lucigenin can undergo significant redox-cycling in the presence of reductases, generating itself artifactual superoxides [16], these findings were plump women galleries confirmed by the inhibition of luminescence by SOD administration. Neverthless, the oxidative hypothesis is by no means the plump women galleries only hypothesis that can be considered in the general context of the scope of use of antioxidants drugs in NAFLD. Vitamin E (α-tocopherol), a potent fat-soluble antioxidant with capacity to scavenge free radicals could not inhibit the development of steatosis in this model. Besides, in this study, vitamin E did not change the profile of biochemical and oxidative stress variables.
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