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The following hypotheses will be tested: obesity causes hepatic fat accumulation because of excessive fatty acid release from fat tissue and increased free fatty acid availability, increased hepatic (liver) fat content causes insulin-resistant glucose (sugar) production by the liver and altered liver protein synthesis, increased hepatic fat content causes increased fatty liver / causes of lipid (fat) peroxidation, hepatic inflammation, necrosis and fibrosis, and marked weight fatty liver / causes of loss improves NAFLD once patients are weight stable. Condition Intervention Non-Alcoholic Fatty Liver Disease Drug: niacin, fenofibrate, pioglitazone MedlinePlus consumer health information Study Type: InterventionalStudy Design: Treatment, Randomized, Single Blind, Active Control, Factorial Assignment, Efficacy Study Further study details as provided by National Institute of fatty liver / causes of Diabetes and Digestive and Kidney Diseases (NIDDK): Primary Outcomes: 1.
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