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fat fatty , volatile fatty acid , plump thumbs , cardiovasculardisease, february 2004 report: the “hidden” liver disease, pegilated, omega3 fatty acid , felice poli, gold n plump , fatty js , protein calorie malnutrition, plump galleries , triglycerides, plump dumpling , autoimmune disorder, what is nonalcoholic fatty liver diseasee, seronegative, saturated and unsaturated fatty acids , alcohol/addiction/illegaldrugs news, weight loss, AD - School of Biological Sciences, University of Auckland, Auckland, New Zealand. a.xu@auckland.ac.nz PMID- 12840063 Article mirrored from Nutrition Journal at 12am on November 07, 2003     Nutrition Journal Volume 2 • Full text • PDF (432KB) Research fatty post Vitamin C and Vitamin E in Prevention of fatty post Nonalcoholic Fatty fatty post Liver Disease (NAFLD) in Choline Deficient Diet Fed Rats Claudia PMS Oliveira1 , Luiz Carlos da Costa Gayotto2 , Caroline Tatai1 , Bianca Ishimoto Della Nina1 , Emerson S Lima4 , Dulcinéia SP Abdalla4 , Fabio P Lopasso1 , Francisco RM Laurindo3 and Flair José Carrilho1 1Department of Gastroenterology of Medical School of University of São Paulo (USP), São Paulo, Brazil 2Department of Pathology (LIM14) of Medical School of University of São Paulo (USP), São Paulo, Brazil 3Departament of Heart Institute of Medical School of University of São Paulo (USP), São Paulo, Brazil 4Department of Clinical and Toxicological Analyses of School of Pharmaceutical Sciences of University of São Paulo (USP), São Paulo, Brazil Nutrition Journal 2003 2:9 The electronic version of this article is the complete one and can
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These therapeutic effects resulted partly from the ability of adiponectin to increase carnitine palmitoyltransferase I activity and enhance hepatic fatty acid oxidation, while it decreased the activities of two key enzymes fatty js involved in fatty acid synthesis, including acetyl-CoA carboxylase and fatty acid synthase. Furthermore, adiponectin fatty js treatment could suppress the hepatic production of TNF-alpha and plasma concentrations of this proinflammatory cytokine. Adiponectin was also effective in ameliorating hepatomegaly, steatosis, and alanine aminotransferase abnormality associated with nonalcoholic obese, ob/ob mice. These results demonstrate a novel mechanism of adiponectin action and suggest a potential clinical application of fatty js adiponectin and its agonists in the treatment of liver diseases.
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