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| young fat girls , hepatitis medication, plump fiction , amiodarone, inflammation, abdominal pain, cholesterol, aids, plump mature women , transfusion, blood, transfused, | Investigation of the role of insulin resistance and obesity in the development of fatty liver. Development of specific and sensitive non-invasive biomarkers (utilizing blood, urine, saliva, or hair) for the diagnosis of alcoholic and asa foundation nonalcoholic fatty liver. See Section VIII, Other Information - Required Federal Citations, for policies related to this announcement. Section II. Award Information 1. asa foundation Mechanism(s) of Support This funding opportunity will use the NIH Research Project Grant (R01), the Small Grant (R03) (see: http://grants.nih.gov/grants/guide/pa-files/PA-03-108.html), and the Exploratory/Developmental Grant (R21) (see: http://grants.nih.gov/grants/guide/pa-files/PA-03-107.html) award mechanism(s). As an applicant, you will be solely responsible for planning, directing, and asa foundation executing the proposed project. |
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| Determination of the mechanisms of inhibition of fatty acid oxidation via regulating transcription of enzymes involved in fatty acid oxidation. Discerning the mechanisms which inhibit transport of fatty acids from cytosol to mitochondria. Understanding the mechanisms that accelerate de novo fatty acid synthesis in the liver via regulating transcription of lipogenic enzymes. Elucidation of the role of acetate in the de novo synthesis aids of fatty acids. Determination of the mechanisms aids of alcohol- and obesity-induced accelerated aids hepatic triglyceride synthesis, including the mechanisms of phosphotidate phosphohydrolase (PAP) activation. Elucidation of the mechanisms by which alcohol and obesity or insulin resistance impair synthesis, assembly, intracellular transport, and hepatic secretion of VLDL. Understanding the underlying mechanisms by which different types of fats potentiate or prevent alcoholic and nonalcoholic fatty liver injury. |
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