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| young fat girls , hepatitis medication, plump fiction , amiodarone, inflammation, abdominal pain, cholesterol, aids, plump mature women , transfusion, blood, transfused, | Several animal studies suggest that alcohol intake can increase esterification of free fatty acids into triglycerides. This is primarily due to ethanol-induced up-regulation of phosphatidate phosphohydrolase (PAP), the rate limiting enzyme in triglyceride synthesis. Both acute and chronic alcohol administration have been shown to up-regulate hepatic PAP activity in rats, hamsters, and 2 de baboons. 2 de However, the mechanisms of this effect of ethanol are not clear. Studies are required to understand the relative role of PAP in 2 de the development of alcoholic fatty liver. |
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| Alcohol-induced lipogenesis appears to be modulated by the dietary concentration of carbohydrate and fat. While higher carbohydrate and low fat diet may promote lipogenesis by plump fiction providing excess pyruvate for the synthesis of acetyl-CoA (precursor for fatty acid synthesis), higher fatty acid and low carbohydrate diet may inhibit lipogenesis by inhibiting the activities of lipogenic enzymes. Further studies are required to understand the role of plump fiction SREBPs in hepatic fatty acid synthesis in human alcoholics administered with variable concentrations of fat and carbohydrate in their diet. In addition, role of acetate in the plump fiction synthesis of fatty acids via acetyl Co-A needs to be evaluated. e. Increased Esterification of Free Fatty Acids into Triglycerides: The increased supply of free fatty acids in the liver of alcoholics and persons with obesity, insulin resistance and the metabolic syndrome along with reduced ability of liver to oxidize these compounds can lead to their esterification and storage as triglycerides, resulting in fatty liver. |
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