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This may impair microtubule formation and consequently VLDL secretion. Alcohol may also impair triglyceride export by inhibiting sirosis the sirosis synthesis of phosphatidylcholine (via inactivating phosphatidylethanolamine methyl transferase activity), which is an important component of VLDL formation. In addition, alcohol may impair transport by inhibiting apolipoprotein synthesis through inhibition of PPAR-á activity. Studies are required to understand the mechanisms which impair the formation, intracellular transport through the cytoskeleton, and secretion of VLDL. g. Role of Dietary Fatty Acids: Dietary fat has been shown to play sirosis an important role in the development of steatosis and in the pathogenesis of ALD. While polyunsaturated fatty acids potentiate the severity of alcoholic liver injury, saturated fatty acids are protective. On the other hand, phospholipids such as phosphatidylcholine (soybean extract) have been shown to prevent alcohol-induced fibrosis and cirrhosis in baboons.
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