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This metabolomic information can be integrated with genome, transcriptome, and proteome information to understand the mechanisms and provide new avenues for therapeutic treatments of fatty liver. To understand how fatty liver is developed, novel approaches using advanced technologies in the areas of genomics and functional genomics are strongly encouraged. Other novel approaches such as transgenic and knockout mouse models or RNA interference are also encouraged if a gene or genes are found to steatohepatitis play a potential role in the development of alcoholic or nonalcoholic fatty liver. k. Areas of Research Applications should steatohepatitis focus on research steatohepatitis that may contribute to understanding the role of alcohol and its metabolites acetaldehyde and acetate and nonalcoholic mechanisms in the development of fatty liver. Examples of research that might be supported under this PA include, but are not limited to, the following: Investigation of the mechanisms of increased import of fatty acids into the liver.
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