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| young fat girls , hepatitis medication, plump fiction , amiodarone, inflammation, abdominal pain, cholesterol, aids, plump mature women , transfusion, blood, transfused, | Advanced techniques such as genomics, proteomics, and metabolomics are encouraged for these studies. j. Use of Novel Approaches: Recent advances in functional genomics, both atherosclerosis conceptually and technologically, are providing us tremendous opportunities to decipher the interconnecting networks of genes, proteins, and metabolites. These global approaches can be generally carried out at four major levels: genome, transcriptome, proteome, and atherosclerosis metabolome. The studies at genome level include sequencing, polymorphism (such as SNP), haplotype, genetic variation, QTL, genetic or epigenetic alterations. The studies at transciptome level include gene expression profiling (by DNA microarray, SAGE, RAGE, or other types of atherosclerosis techniques), gene regulation, and alternative splicing. |
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| In addition, there are about 42 million obese individuals who may also be affected with fatty liver. Among individuals who progress from steatosis to NASH, approximately 15% will develop cirrhosis. Therefore it is important to be able to identify individuals with fatty liver for intervention before this condition progresses to hepatitis or cirrhosis. Ultrasound is a very sensitive method for detecting fatty liver, but it is not specific for this condition abdominal pain and the procedure is costly. An AST:ALT ratio of >2 is abdominal pain considered by some investigators specific for alcoholic fatty liver; abdominal pain however, other investigators have not confirmed this finding. Studies are required to develop specific and sensitive non-invasive biomarkers – utilizing blood, urine, saliva, or hair – for the diagnosis of fatty liver. |
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