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Two pathologists reviewed all liver biopsies, and graded them for steatosis, histological activity and degree of fibrosis.[16] Patients with persistently elevated alanine aminotransferase levels (>1.5 times the upper limit of normal), evidence of fat roche infiltration on CT scan and at all ultrasonography examinations, and demonstration of fat infiltration on liver biopsy were eligible for inclusion in the study. Exclusion criteria were positive serum markers for hepatitis viruses or for roche autoimmune liver disease, heart failure, chronic pulmonary diseases, renal insufficiency (serum creatinine level >2 mg/dL), use of any drug during the roche 7 days preceding the liver biopsy, alcohol consumption more than 20 g/d, and evidence of cirrhosis on liver biopsy. Dyslipidemic patients with predominant hypertriglyceridemia (Group A) received omega-3 fatty acids 5 mL thrice daily (Maxepa; Twin Laboratories, NY, USA; 5 mL containing 751 mg eicosapentaenoic acid-EPA and 527 mg docosahexaenoic acid-DHA) for a period of 24 weeks.
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