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| omega minus three fatty acids , hepatic steatosis, free cme credit, medical headlines, plump amateur , fatty acid chain , marie claire, plump granny , what are trans fatty acids , seroconversion, dress up fatty , immune, plump jack , fatty acids definition , svr, weber christian disease, plump dj's , | identifier NCT00063635 California University of California, San Diego, San free access Diego, California, 92103, United States; Recruiting Ileana Rubio 619-471-9429 irubio@ucsd.edu Zana Parman 619-543-5226 zparman@ucsd.edu Joel Lavine, free access MD, PhD, Principal InvestigatorJeffrey Schwimmer, MD, Sub-Investigator University of California, San Francisco, San Francisco, California, 94143, United States; Recruiting Danuta Filipowski 415-476-1756 filipowskid@peds.ucsf.edu Nathan Bass, MD, PhD, Principal InvestigatorPhilip Rosenthal, MD, Sub-InvestigatorIndiana Indiana University, Indianapolis, Indiana, 46202, United States; Not yet recruiting Maryland Johns Hopkins University, Baltimore, Maryland, 21205, United States; Recruiting Debra Peglow 410-614-8583 dpeglow1@jhmi.edu |
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| Identifier: NCT00063635 Purpose The purpose of this study is to determine if therapeutic modification of insulin resistance or oxidative stress leads to improvement in immune serum or histologic indicators of immune liver injury or quality of life. Condition Intervention Phase Fatty Liver Drug: Metformin Drug: Vitamin E Drug: Placebo Phase III MedlinePlus related topics: Liver DiseasesGenetics Home Reference related topics: Liver Diseases Study Type: InterventionalStudy Design: Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study Official Title: Clinical Research Network in Nonalcoholic Steatohepatitis: Treatment of Nonalcoholic Fatty Liver Disease in Children immune (TONIC) Eligibility Ages Eligible for Study: 8 Years - 15 Years, Genders Eligible for Study: Both Criteria Age 8-15 years at first screening visit Histologic evidence of Nonalcoholic Fatty Liver Disease (NAFLD) - biopsy cannot be older than 6 months as of randomization ALT level >60 U/L at time of screening and on one previous occasion determined at least one month but no greater than 6 months prior to screening ALT Consent Location and Contact Information Please refer to this study by ClinicalTrials.gov |
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