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2003 Jul;112(1):91-100. Links The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice.Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ.School of Biological Sciences, University of Auckland, Auckland, New Zealand. tracheoesophageal fistula a.xu@auckland.ac.nzAdiponectin has recently been shown to be a promising candidate for the treatment of obesity-associated metabolic syndromes. Replenishment of recombinant adiponectin in mice can decrease hyperglycemia, reverse insulin resistance, and cause sustained weight loss tracheoesophageal fistula without affecting food intake. Here we report its potential roles in alcoholic tracheoesophageal fistula and nonalcoholic fatty liver diseases in mice. Circulating concentrations of adiponectin decreased significantly following chronic consumption of high-fat ethanol-containing food.
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