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In Western countries, prevalence in the general population of non-alcoholic steatohepatitis pegylated (NASH) ranges from 1% to 5% and that of non-alcoholic pegylated fatty liver disease (NAFLD) from 15% to 39%.[1],[2] Recent reports suggest that many cases of cryptogenic liver cirrhosis may be related to unrecognized NASH.[3] NASH and NAFLD may be either idiopathic or secondary to conditions like type II diabetes mellitus, dyslipidemia, obesity, ingestion of certain drugs and jejunoileal bypass surgery.[4] In some patients, NAFLD follows a relatively benign course and remains stable for years.[5] Thus, treatment should be reserved pegylated for patients who are at risk of developing severe liver disease, if these can be identified. NAFLD associated with obesity may improve with weight reduction, though data on this are inconsistent.[6],[7],[8] In patients with diabetes mellitus or dyslipidemia, appropriate metabolic control does not reliably reverse fatty liver.
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