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(74) Prior to taking vitamin E, all appendicitis patients were given a six-month treatment of dietary therapy with appendicitis caloric consumption limited to 30 kcal/kg appendicitis body weight/day. During the weight reduction period, patients with NAFLD lost an average of 6 kg and had a significant lowering of ALT and AST to near normal limits (Table 5). The NASH patients lost the same amount of weight but did not experience the same drops in AST and ALT. After 12 months on 300 IU [alpha]-tocopherol, however, AST and ALT levels in the NASH patients dropped significantly. AST fell to within normal limits for all NASH patients and ALT values were near normal. ALT and AST values for the NAFLD patients were not appreciably affected by [alpha]-tocopherol. Most importantly, repeat liver biopsy in nine of the 12 NASH patients after 12 months of [alpha]-tocopherol treatment revealed that inflammation and fibrosis were significantly improved in five, and the remaining four had significant improvement in steatosis.
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