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pounds) per week for children and 1600 grams (3.5 pounds) per week for adults has been suggested. (56,57) Magnesium Given the role of insulin resistance in NAFLD and the incidence of obesity and type 2 diabetes in NASH, addressing the "first hit" of insulin resistance and triglyceride storage in hepatocytes is crucial. organ Depletion of magnesium from normal cells creates cellular insulin resistance. (58) Magnesium levels are related to organ insulin resistance in type 1 and 2 diabetics and in nondiabetics. In patients with type 1 diabetes, low serum and plasma magnesium levels have been documented in several trials and are considered a relatively common finding; 25-48 percent of type 2 diabetics have been shown to have low blood magnesium levels. (59-61) Low plasma magnesium is significantly correlated with decreased glucose disposal in both type 1 and type 2 diabetes.
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