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The first study big n plump looked at 400-1200 IU of dl-[alpha]-tocopherol in children 8-14 years big n plump of age. (73) All children in the study were obese and had a history of elevated AST and ALT levels for over three months with evidence of fatty liver on liver ultrasonography. Median serum ALT was approximately 3.9 times the upper limit of normal, AST was 2.3 times the upper limit of normal, and alkaline phosphatase was 1.5 times the upper limit of normal. All of the children were considered to have NASH even though their diagnoses were not confirmed by liver biopsy. Each participant was started on 400 IU vitamin E and had liver enzyme levels repeated monthly. If AST and ALT values were not within normal limits one month after beginning treatment, the dose of vitamin E was raised by 400 IU per month to a maximum of 1200 IU.
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