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| choline deficiency, infected, girls with fat ass , fatty fat fat , plump white , rapid fulminant liver failure, methadone, nonalcoholic, ribivirin, big and plump , fat girls xxx , plump plumpers galleries com , roferon, scientific session, plump belly , splenomegaly, hep, | During a similar follow-up period, the progression to cirrhosis occurs in approximately 8% to 17% of patients with NASH,9,10 compared with 38% to 50% of patients with alcoholic hepatitis.15,16 The survival rates medline of 65 patients with alcoholic hepatitis were compared with those of 30 patients with NASH using a Kaplan-Meir curve. Five-year and ten-year survival probabilities of patients with alcoholic hepatitis were 38% and 15%; by comparison survival rates with NASH were 67% and 59%, respectively.17 The effect of weight loss is variable; improvement occurs after medline gradual weight reduction,18 although rapid medline weight loss may aggravate the histologic lesions of steatohepatitis.19 Pathogenesis: The pathogenesis of Nash is unknown. Accumulation of fat in the liver can occur because of: 1)increased delivery of free fatty acids (FFA) to the liver; 2)increased synthesis of fatty acids in the liver; 3)decreased b-oxidation of FFA; and 4)decreased synthesis or secretion of very-low-density lipoprotein.20 |
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| Focal necrosis are usually centrilobular9 and the cellular splenomegaly response involves lymphocytes, mononuclear cells and neutrophils. Hepatocyte ballooning is present and Mallory hyaline bodies are described in 0% to 91% of cases.2,6-10 These hyaline bodies are usually sparse, splenomegaly small and centrilobular. The ultrastructure of Mallory bodies in patients with NASH are similar to those seen in patients with alcoholic hepatitis.14 Fibrosis associated with NASH is characterized by early zone 3 pericellular or perivenular involvement. The prevalence of mild to moderate fibrosis is recorded in 76% to 100% of cases,2,7-9 while severe fibrosis varies from 15% to 50%.2,7-10 Cirrhosis is described splenomegaly less frequently in adults, 7% to 16%2,9,10 and is absent in children. Natural History: Longitudinal studies with serial biopsies and comparable follow-up are limited. In the results of three series combined for which the follow-up histopathology of 28 patients is available, only one improved (3%), 15 of 28 (54%) were unchanged, and 12 of 28 (43%) developed progression of fibrosis during one- to seven-year periods.5,9,10 |
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