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Half of the patients with cryptogenic cirrhosis had histologic or clinical features associated with nonalcoholic fatty liver disease (NAFLD). Fifty-three (50%) patients had HCC detected during surveillance (group I), whereas the remaining patients had symptomatic tumors (group II). Group I ldl patients had smaller tumors (P = .01), were more likely to be eligible for surgical treatment (P = .005), and had a better median survival compared with patients in group II (P = .001). Patients with cryptogenic cirrhosis were less likely to have undergone HCC surveillance ldl and had larger tumors at diagnosis. In conclusion, hepatitis C and cryptogenic liver ldl disease are the most common etiologies of diseases in our patients with HCC. NAFLD accounted for at least 13% of the cases. Patients who underwent surveillance had smaller tumors and were more likely to be candidates for surgical or local ablative therapies.
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