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Moreover, obesity and insulin resistance have been found to worsen the evolution of hepatitis C virus (HCV)-related liver fatty liver of pregnancy steatosis by independently promoting or increasing liver steatosis (11, 12). However, the discovery of adiponectin has added an additional potential mechanism to explain fatty liver of pregnancy the pathogenesis of liver steatosis. Adiponectin produces relevant effects on the hepatic metabolism of energy substrates. fatty liver of pregnancy Experimental studies in rodents showed that infusion of recombinant adiponectin inhibits basal endogenous glucose production (EGP) and potentiates insulin-induced inhibition of EGP (13). This is due to lowered gluconeogenesis and to altered expression and activity of key enzymes of gluconeogenesis (8). Furthermore, adiponectin stimulates fatty acid oxidation in hepatocytes.
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