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Condition Intervention Phase HIV InfectionsNon-Alcoholic Fatty Liver Disease Drug: antioxidant vitamin E, betaine Behavior: weight reduction and exercise Phase II MedlinePlus related topics: AIDS Study Type: InterventionalStudy Design: Treatment, Randomized, Open Label, medline Placebo Control, Single Group Assignment Official Title: Non-Alcoholic Fatty Liver Disease (NAFLD) in HIV: The Role of Nutritional Interventions Further medline study details as provided by University Health Network, medline Toronto: Primary Outcomes: The change in grading of inflammation assessed by liver biopsy from month 0 to month 12 of the studySecondary Outcomes: liver histology for steatosis and fibrosis staging; liver immuno-histochemistry for adducts fo MDA; a product of LP; alpha-smooth muscle actin (alpha-SMA); a marker of hepatic stellate cell activation; transforming growth factor (TGF-beta); a profibrogenic cytokine involved in fibrogenesis; liver lipid peroxides and TNP-alpha; liver steatosis and volume will be assessed by ultrasound; liver enzymes and IR (HOMA and QUICKLY) will also be measured; INF-alpha; lipid peroxide, vitamin E and C will aslo be
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