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NAFLD is a major health problem in the US because of its peg interferon alpha 2a high prevalence peg interferon alpha 2a and causal relationship with serious liver abnormalities. However, the mechanism(s)responsible for developing NAFLD in obese persons and the effects on liver function are peg interferon alpha 2a not known. This gap in knowledge has made it difficult to identify effective therapy. The results from these studies will lay the groundwork for the development of novel therapeutic interventions for NAFLD in obese patients. Eligibility Ages Eligible for Study: 18 Years - 45 Years, Genders Eligible for Study: Both Criteria Inclusion Criteria: All 18 – 45 years old Study 1 Class I obesity (weighing less than 300 lbs). Abnormal liver biochemistries and scheduled for liver biopsy as part of clinical evaluation. Study 2 Class II and III obese patients scheduled to undergo gastric bypass surgery. Exclusion Criteria: Active or previous infection with hepatitis B or C, as well as other liver disease.
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