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Affects 24% of U.S. patients More common in women hcv drugs Risk Factors or Associated Conditions Obesity Occurs in 66% of all obese patients Occurs in 90% of patients at twice their Ideal Weight Hyperglycemia (75% of NASH patients) Metabolic Syndrome Type II Diabetes Mellitus Hyperlipidemia (especially Hypertriglyceridemia) Rapid weight loss Symptoms Fatigue Malaise Right upper quadrant pain hcv drugs Signs Hepatomegaly Differential Diagnosis hcv drugs Viral Hepatitis Alcoholic Hepatitis Labs Liver Function Tests: Aminotransferase Aspartate Aminotransferase (AST) increased 2-3 fold Alanine Aminotransferase (ALT) increased 2-3 fold Radiology Right upper quadrant ultrasound Increased liver echoes Good sensitivity and Specificity Does not determine disease severity Diagnosis Liver Biopsy (grades degree of fatty infiltration) Fatty change Hepatocyte injury Fibrosis variably present Management See Prevention of Liver Disease Progression Weight Reduction Liver Function Tests improve or normalize Fibrosis
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