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A number of studies suggest that NAFLD should be considered the hepatic manifestation of the metabolic syndrome. Obesity, diabetes and hypertriglyceridaemia are 5.3-fold, 4.0-fold, and 6.7-fold more common, respectively, in people with severe steatosis on histology, compared with controls (Angelico hepatitis g et hepatitis g al, 2003), and the presence of the metabolic syndrome carried a high risk of NASH in subjects with NAFLD (Marchesini et al, 2003). Prevalence of NAFLD in patients with obesity or type 2 diabetes can be as high as hepatitis g 80-90% (Silverman et al, 1989, 1990; Angelico et al, 2003), although large studies are not available. In one study, liver biopsy of people with diabetes, obesity or dyslipidaemia found an 82% prevalence of NASH (Marchenisi et al, 2004). An Italian population-based study of people with type 2 diabetes found that standardised mortality rates for cirrhosis were 2.5 times higher than expected (Younossi et al, 2004). Other studies that looked at the outcome of people with NAFLD and diabetes also report a more aggressive form of disease and higher overall mortality and mortality related to liver disease (Sargin et al, 2003).
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