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The areas of focus include investigations of mechanisms by which alcohol and nonalcoholic physiologic processes: a) accelerate import of free fatty acids into hepatocytes; b) impair mitochondrial â-oxidation of fatty acids; c) impede the entry plump videos of free fatty acids into mitochondria; d) plump videos promote de novo fatty acid synthesis; e) promote esterification of free fatty acids into triglycerides; and f) disrupt export of triglycerides from hepatocytes. Research to develop non-invasive biomarkers for fatty liver using genomics, proteomics, and metabolomics, is also encouraged. Proposals investigating the modulating effects of dietary fatty acids, obesity, diabetes, insulin resistance, and components plump videos of the metabolic syndrome on alcoholic and nonalcoholic fatty liver are also encouraged. Understanding these mechanisms may help develop strategies for the prevention of accumulation of fat within the liver which may block or delay the progression of fatty liver to active hepatitis, fibrosis, and cirrhosis.
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