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| plump mt , pegylated interferons, plump thighs , copegasus, hepatitis c treatments, drugs, crystallography, reference, plump lip , tests, dosing, symptoms, plump mature , treatments for nonalcoholic fatty liver diseasee, fatty ass , | Hatzitolios and colleagues attempted to minimize this phenomenon by including only patients with persistently raised aminotransferase levels. Revealingly, after several pilot studies had clinical proteomics suggested ursodeoxycholic acid to be beneficial in the treatment of nonalcoholic steatohepatitis,[11],[15] a subsequent large randomized placebo-controlled trial that examined liver histology as well clinical proteomics as liver enzymes demonstrated it was no better than placebo.[16] Therefore, before omega-3 fatty acids, atorvastatin or clinical proteomics orlistat can be suggested for routine treatment among patients with NAFLD, further evidence with adequately powered randomized, placebo-controlled trials with histological endpoints need to be performed. Unfortunately, no treatment has been proven to be efficacious with these stringent criteria. |
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| A diet high in polyunsaturated fatty acids has been shown to be associated with liver enzyme improvement in obese subjects with fatty liver.[10] Similarly, atorvastatin and orlistat have improved liver enzymes tests as well as liver steatosis in a handful of patients over 6-12 months.[11],[12]However, promising data from uncontrolled trials without histological endpoints can be misleading. Ultrasonography is insensitive at tests detecting low grades of hepatic steatosis and cannot assess the more sinister pathological changes of inflammation tests or fibrosis.[13] Improvement of liver enzymes over time does not correlate sufficiently with improvement in fibrosis stage to be clinically useful. In addition, improvement may simply reflect 'regression to the mean',[14] as NAFLD patients with high enzymes naturally fluctuate between normal and abnormal levels over time. |
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