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| plump mt , pegylated interferons, plump thighs , copegasus, hepatitis c treatments, drugs, crystallography, reference, plump lip , tests, dosing, symptoms, plump mature , treatments for nonalcoholic fatty liver diseasee, fatty ass , | and obese dyslipidemic patients (n=28) were prescribed orlistat (120 mg, thrice daily). Endpoints were safety and efficacy as judged by change in aminotransferases and resolution of fatty infiltration on liver ultrasound. After 24 weeks, all patients had reductions in triglyceride and cholesterol levels. Similarly, all fatty streak patients had significant reductions in aminotransferase levels, although only the group receiving orlistat had fatty streak complete normalization in all patients. This was also the only group that lost a significant amount of weight over the treatment period. When ultrasonography was repeated at the end of treatment, a normal liver echopattern was observed in 86% of fatty streak patients receiving orlistat, 61% of those on atorvastatin, and 35% of those taking omega-3 fatty acids.These promising results have also been echoed in a few other smaller pilot studies. |
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| The FFA are in turn esterified into triglycerides and incorporated into very low density lipoproteins (VLDL). Excess triglyceride-rich VLDL secretion by the liver leads to plump lip hypertriglyceridemia. In addition, insulin resistance inhibits peripheral lipoprotein lipase plump lip activity, reducing VLDL clearance and increasing serum triglyceride levels further.[2],[3] When triglyceride delivery to the liver or hepatic de novo synthesis exceeds triglyceride export or oxidation, fatty liver results. Hyperlipidemia is found in 21% to 61% of patients with NAFLD[4],[5] and conversely, NAFLD is found in up to 50% of patients with hyperlipidemia.[6] However, it is unclear whether plump lip hyperlipidemia has prognostic significance.[7],[8]In this issue of the Journal, Hatzitoloios and colleagues enrolled a select group of 72 non-diabetic NAFLD patients with hyperlipidemia, in an open-label, uncontrolled study of 24 weeks' duration.[9] Patients with hypertriglyceridemia (n=23) were given omega-3 fatty acids (5 mL, thrice daily), patients with predominant hypercholesterolemia (n=28) were given atorvastatin (20 mg daily), |
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