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| alcohol related fatty liver, bbw plump , symptoms liver disease, fatty mcblog , plump ebony , proteomic biomarkers, plump girl , medicine articles, hyperlipidemia, cme, polyethylene glycol, omega 3 fatty acid fish oil , peginterferon alpha 2a, ribavirin interferon, nonalcoholic steatohepatitis, side effects, lemagazine, plump booty , sirrosis, seropositive, self injection, | (2) In a study of 105 obese patients (BMI over 35), independent predictors of fibrosis were hypertension (140/90 or above), an elevated index of insulin resistance, and a serum ALT level over 40. (18) This population is not uncommon; 26 percent cirosis of the cirosis American population is considered obese (BMI over 30 kg/[m.sup.3]). (19) Pathogenesis of NAFLD and NASH Insulin Resistance and its Relationship to Fatty Liver Multiple authors have proposed that NASH be included as a clinical feature in the metabolic disorder of insulin resistance. (20-22) Insulin resistance, estimated to cirosis occur in approximately 25 percent of the general population, has been associated with hyperinsulinemia, abnormal glucose tolerance, type 2 diabetes mellitus, hypertriglyceridemia, decreased high-density lipoprotein levels, hypertension, abnormal fibrinolysis, increased visceral fat accumulation, hyperuricemia, polycystic ovarian syndrome, and other lipid abnormalities. |
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| (14) Histopathology on liver biopsy in NASH is identical to the damage in alcohol abuse. The presence of macrovesicular steatosis, inflammatory cell infiltration, hepatocyte ballooning, and necrosis are the main histological features of NASH. (5,14) Although hepatic iron does appear to be a factor increasing risk proteomic biomarkers for fibrosis, (17) elevated ferritin is only found in about 50 percent of proteomic biomarkers patients. Elevated ferritin levels, however, do not always indicate elevated hepatic iron stores. In NASH, hepatic iron levels are usually normal. Elevated ferritin and transferrin levels, when they do occur, may be proteomic biomarkers the result of hepatocyte necrosis. (2) Several studies have examined signs and symptoms that correlate with presence of fibrosis (Table 1). In a study of 144 patients with NASH, over age 45, the presence of type 2 diabetes and a body mass index (BMI) of 30 or over were predictive of fibrosis, and indicated the need of a liver biopsy to provide both an accurate diagnosis and to serve as a baseline to determine the efficacy of treatment. |
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