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| plump lip , tests, dosing, symptoms, plump mature , treatments for nonalcoholic fatty liver diseasee, fatty ass , fatty acid definition , hep c, n 3 polyunsaturated fatty acids , combo, maldi, encephalopathy, hepatitis a, copegus, hcv drug, hcv medication, liver, plump dj , | OBJECTIVE: Nonalcoholic steatohepatitis (NASH) is a common but poorly understood liver disease. Our aim was to study a large group of patients referred for Hepatology consultation to further characterize this disorder, in particular its demographics and range of severity. We also sought to better open access understand its etiology and its relationship to the insulin resistance syndrome, known as the open access metabolic syndrome or syndrome X. METHODS: Retrospective review of 90 patients seen over a 4-yr period. RESULTS: Ninety open access patients aged 14-70 with NASH seen at the Liver Clinics at either the University of Tennessee or the Medical University of South Carolina. Eleven had complications of portal hypertension and seven of these had undergone or were awaiting transplantation. NASH was seen in nine families either in siblings or in subsequent generations. |
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| IR was confirmed in 65 patients (98%) symptoms with NASH, and 55 (87%) fulfilled minimum criteria for IRS. IR was found in lean as well as in overweight and obese patients. The IR values and the prevalence of IRS (75% vs. 8.3%) were significantly higher in those with NASH than in comparable cases of symptoms HCV. Hyperinsulinemia was attributable to increased insulin secretion rather than decreased hepatic extraction. In conclusion, most patients with symptoms NASH have IRS, and there is a near-universal association between NASH and IR irrespective of obesity. IR is present in mild as well as advanced cases of NASH but is unusual in chronic HCV of similar fibrotic severity. AD - Storr Liver Unit, Westmead Millennium Institute, University of Sydney, New South Wales, Australia. PMID- 11826411 12TI - Ninety patients with nonalcoholic steatohepatitis: insulin resistance, familial tendency, and severity of disease. AU - Willner IR; Waters B; Patil SR; Reuben A; Morelli J; Riely CA SO - Am J Gastroenterol 2001 Oct;96(10):2957-61. |
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