Ghrelin was reduced (mean nude fat girls glycogen storage disorder

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Ghrelin was reduced (mean +/- SD, 226 +/- 72 pmol/liter in NAFLD vs. 303 +/- 123 in controls; P glycogen storage disorder < 0.0001). In relation to quartiles of body mass index, ghrelin progressively decreased in controls (P = glycogen storage disorder 0.003), but not in patients (P = 0.926). In relation to quartiles of HOMA-R, ghrelin decreased in both groups, and significantly correlated with HOMA-R. After adjustment for age and sex, HOMA-R was the sole factor significantly associated with low glycogen storage disorder ghrelin in the whole group (odds ratio, 5.79; 95% confidence interval, 2.62-12.81; P < 0.0001) and specifically in NAFLD (2.96; 1.12-7.79; P = 0.028). The study suggests that insulin resistance is a major factor controlling ghrelin levels in subjects with and without NAFLD.PMID: 14671152 [PubMed - indexed for MEDLINE]  Display  Summary Brief Abstract Citation MEDLINE XML UI List LinkOut ASN.1
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