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2003 Dec;88(12):5674-9. Links Low ghrelin concentrations in nonalcoholic fatty liver disease are related to insulin resistance.Marchesini G, Pagotto U, intron Bugianesi E, De Iasio R, Manini R, Vanni E, Pasquali R, Melchionda N, Rizzetto M.Unit of Metabolic Diseases, Alma Mater intron Studiorum, University of Bologna, I-40138 Bologna, Italy. giulio.marchesini@unibo.itSeveral physiological and pathophysiological conditions, including changes in body fat, food intake, and insulin resistance, are known to be associated with variations in plasma ghrelin concentrations. We tested intron the hypothesis that insulin resistance exerts a primary role by measuring ghrelin in 86 patients with nonalcoholic fatty liver disease (NAFLD), a condition in which insulin resistance is relatively independent of obesity. Compared with 40 matched healthy subjects, patients with NAFLD had similar glucose levels and higher plasma insulin and insulin resistance [homeostasis model assessment (HOMA)-R index] by over 60%.
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