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Insulin resistance, through the inhibition of lipid oxidation and increased fatty acid and triglycerides synthesis, is believed to be a key factor in the development of fatty liver. Moreover, insulin resistance states, such as obesity and diabetes, are also characterized by elevated expression and production homocystinuria of several cytokines; homocystinuria of particular interest are cytokines produced by adipose tissue, the so-called adipokines (adiponectin, leptin, resistin, TNF, TGFß and PAI-1). Their role in the development of diabetes and homocystinuria other obesity complication has been suggested (6). Adiponectin, also known as ACRP30, is a 30 kDa protein abundantly and selectively expressed in white adipose tissue.
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