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NAFLD and nonalcoholic steatohepatitis (NASH) are the two most common chronic liver diseases plump movies in United States general population with a prevalence of 20% and 3%, respectively. Hepatic steatosis is frequently associated with plump movies obesity, type 2 diabetes, and hyperlipidemia with insulin resistance as a key pathogenic plump movies factor. A two-hit theory best describes the progression from simple steatosis to NASH, fibrosis, or cirrhosis. These two hits consist of the accumulation of excessive hepatic fat primarily owing to insulin resistance, and oxidative stress owing to reactive oxygen species (ROS). Mitochondria are the major cellular source of ROS in cases of NASH. Currently, treatment is focused on modifying risk factors such as obesity, diabetes mellitus, and hyperlipidemia. Antioxidants such as vitamin E, N-acetylcysteine, betaine, and others may be beneficial in the treatment of NASH.
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