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fat girls xxx , plump plumpers galleries com , roferon, scientific session, plump belly , splenomegaly, hep, national library of medicine, liver infection, plump galleries , awards, plump mt , Intervention: All patients will have dietary intervention by a dietician and will be encouraged to increase physical activity. fatty and skinny Patients will be receiving metformin 850 mg tid for 12 months. Outcome: Improvement of liver enzymes (ALT, AST, GGT) Improvement of metabolic profile: lipid profile, fasting and post-load glucose fatty and skinny and insulin levels, HOMA. Liver histology (repeated liver biopsy after 1 year). Soluble TNF receptors- TNF-receptor P55 and P75. Eligibility Ages Eligible for Study:  18 Years fatty and skinny   -   60 Years,  Genders Eligible for Study:  Both Criteria Inclusion Criteria: ALT > 2 times normal range. Liver histology revealing non-alcoholic steatohepatitis [NASH] (type 2-4), without cirrhosis. Clinical characteristics of the metabolic syndrome as defined by the National Cholesterol Education Program (NCEP), but no overt diabetes.
2-4), without cirrhosis; clinical characteristics of the metabolic syndrome as defined by the NCEP, but no overt diabetes; negative work-up for other causes of liver diseases including alcohol intake < 40 g/week. All patients will undergo liver biopsy and only patients with type plump galleries 2-4 (steatosis + inflammation, or steatosis plus ballooning degeneration, or steatosis plus fibrosis and/or Mallory bodies) but without cirrhosis will be plump galleries included. Patients who received lipid lowering medications or anti hypertensive drugs prior to study will continue the treatment. Patients who will develop overt type 2 DM plump galleries with HbAic > 7% during study will be withdrawn.
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