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The results from these studies will lay the groundwork for the development of nash novel therapeutic interventions for NAFLD in obese patients. Eligibility Ages Eligible for Study: 18 Years - 45 Years, Genders Eligible for Study: Both Criteria Inclusion Criteria: All 18 – 45 years old Study 1 Class I obesity (weighing less than 300 lbs). Abnormal liver biochemistries and scheduled for liver biopsy as part of clinical evaluation. Study 2 Class II and III obese patients scheduled to undergo gastric bypass surgery. nash Exclusion Criteria: nash Active or previous infection with hepatitis B or C, as well as other liver disease. History of alcohol abuse Diabetes Medications that cause liver damage or steatosis. Women who are pregnant or lactating. Location and Contact Information Please refer to this study by ClinicalTrials.gov identifier NCT00262964 Jennifer McCrea, MS 314-362-2846 jmccrea@wuslt.eduMaureen J Egan-Palmer, MS 314-362-3669 eganm@wustl.edu
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