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| To identify the source of triacylglycerols that accumulate in the liver and plasma in nonalcoholic fatty liver disease, the Minnesota investigators recruited nine obese patients who were scheduled for medically indicated liver biopsies. The patients were fed a diet containing stable isotopes of deuterium so that the investigators could trace cme how it was handled hepatically during transitions from the fasting to the fed states. They found that the cme plasma pool of non-esterified fatty acids was the largest contributor to cme fats stored in the liver, followed by newly made fatty acids, and fatty acids derived from the diet. They also found that in the de novo lipogenesis was elevated in the fasting state and was not elevated following a meal as it would be in a healthy person, suggesting a contribution of increased insulin resistance. Related article: Weight Aside, Abdominal Fat Can Trigger Heart Disease and Diabetes Primary source: Journal of Clinical Investigation Disclaimer top Don't miss another MedPage Today Story! |
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