Several physiological and pathophysiological cirosis proteomic biomarkers

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what are fatty acids , drug induced fatty liver, spider angiomas, miss plump , plump jack squaw valley inn , beta oxidation of fatty acids , alcohol related fatty liver, bbw plump , symptoms liver disease, fatty mcblog , plump ebony , proteomic biomarkers, plump girl , medicine articles, hyperlipidemia, Ghrelin was reduced (mean +/- SD, 226 cirosis +/- 72 pmol/liter in NAFLD vs. cirosis 303 +/- 123 in controls; P < 0.0001). In relation to quartiles of body mass index, ghrelin progressively decreased cirosis in controls (P = 0.003), but not in patients (P = 0.926). In relation to quartiles of HOMA-R, ghrelin decreased in both groups, and significantly correlated with HOMA-R. After adjustment for age and sex, HOMA-R was the sole factor significantly associated with low ghrelin in the whole group (odds ratio, 5.79; 95% confidence interval, 2.62-12.81; P < 0.0001) and specifically in NAFLD (2.96; 1.12-7.79; P = 0.028). The study suggests that insulin resistance is a major factor controlling ghrelin levels in subjects with and without NAFLD. AD - Unit of Metabolic Diseases, Alma Mater Studiorum, University of Bologna, I-40138 Bologna, Italy.
Several physiological and pathophysiological conditions, including changes in body fat, food intake, and insulin resistance, are known to be associated with variations in plasma ghrelin concentrations. We tested the proteomic biomarkers hypothesis that insulin resistance exerts a primary role by proteomic biomarkers measuring ghrelin in 86 patients with nonalcoholic fatty liver disease (NAFLD), a condition in which insulin resistance is relatively independent of obesity. Compared with 40 matched healthy subjects, patients with NAFLD had similar glucose levels and higher plasma insulin and insulin resistance [homeostasis proteomic biomarkers model assessment (HOMA)-R index] by over 60%.
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