Mitochondrial injury limits FFA fatty acid ester drug induced fatty liver

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symptoms of fatty liver , hepatitis c virus, cocaine, liver disease treatment, hepatitis c treatment, fatty woman , varices, fatty girl lyrics , fattyliver disease becoming popular, hepatitis c, galactosemia, plump rumps , plump rumps tgp , girls with fat asses , what are fatty acids , drug induced fatty liver, spider angiomas, miss plump , plump jack squaw valley inn , beta oxidation of fatty acids , Focal fatty fatty acid ester change is much less common and less well recognized. These nodules of fatty liver cells are subcapsular. They are usually an incidental finding on ultrasound or CT, presenting as multiple space-occupying lesions of the liver. Such focal fat may appear in patients apparently at risk of developing this change (eg, obese or alcoholic patients). Pathogenesis Triglycerides accumulate in the liver because of increased input through synthesis from FFA or decreased fatty acid ester export as VLDL from the hepatocytes. Increased triglyceride synthesis may result from increased delivery or availability of FFA (from the diet or mobilized from adipose tissue), fatty acid ester from acetylcoenzyme A, or from decreased oxidation of FFA in the liver.
Mitochondrial injury limits drug induced fatty liver FFA oxidation, while apoprotein synthesis necessary for VLDL secretion is depressed, leading to triglyceride accumulation. In phospholipidosis, phospholipids accumulate in association with certain drug use (eg, amiodarone). Liver cells are large and foamy. Etiology Diffuse fatty change of the liver, often zonal in distribution, is associated with drug induced fatty liver many clinical situations. Alcoholism, obesity, and diabetes are the most common causes of macrovesicular fatty liver in developed countries. Other causes include malnutrition (especially the protein-deficient diet of drug induced fatty liver children with kwashiorkor), inborn metabolic disorders (of glycogen, galactose, tyrosine, or homocysteine), drugs (eg, corticosteroids), or systemic illnesses with fever. Microvesicular fatty liver occurs in acute fatty liver of pregnancy, Reye's syndrome, certain drug toxicities (valproic acid, tetracycline, salicylate), or inborn metabolic defects (of the urea cycle enzymes or involving mitochondria in FFA oxidation).
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