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2002 Feb;122(2):274-80. Links Tumor fatty j's pizza necrosis factor alpha promoter polymorphisms and insulin resistance in nonalcoholic fatty liver disease.Valenti L, Fracanzani AL, Dongiovanni P, Santorelli G, Branchi A, Taioli E, Fiorelli fatty j's pizza G, Fargion S.Dipartimento di Medicina Interna, Universita di Milano, Milan, Italy.BACKGROUND & AIMS: Nonalcoholic fatty liver fatty j's pizza disease, which can range from fatty liver alone to nonalcoholic steatohepatitis and cirrhosis, is related to insulin resistance. Tumor necrosis factor alpha (TNF-alpha) may induce insulin resistance, and polymorphisms of its promoter have been associated with an increased release of this cytokine. We analyzed (1) the prevalence of insulin resistance, (2) the prevalence of the 238 and 308 TNF-alpha polymorphisms, and (3) the relationship among TNF-alpha polymorphisms, insulin resistance, and the occurrence of steatohepatitis in 99 patients with nonalcoholic fatty liver diagnosed by ultrasonography and confirmed by histologic analysis in the 53 who underwent biopsy.
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