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Even more important than the fact that a person is obese pegasys is where excess fat is stored on the body. Research has shown that pegasys people who carry excess weight around their middle (abdomen or waist) are most prone to developing insulin resistance. And recent studies have pegasys revealed that the majority of people with nonalcoholic fatty liver disease have central (abdominal) obesity.10,11 What’s Behind the Problem?Nonalcoholic fatty liver disease is known by its acronym, NAFLD. It is a condition characterized by steatosis (fatty liver), inflammation, insulin resistance, and the presence of fibrosis. NAFLD can evolve into cirrhosis, liver failure, and cancer. The pathogenesis of NAFLD is not well understood. Production of tumor necrosis factor-alpha (TNF-a) has been reported to be one of the early events in the many types of liver injury, and together with other TNF-a-dependent cytokines (inflammatory messengers), it may mediate a process of chronic liver injury.
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