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A number of other factors may be involved as well in causing NAFLD and NASH and in progressing big and plump through the stages of NAFLD. What is insulin resistance and how does it relate to NAFLD? Insulin resistance is a state wherein normal signaling pathways big and plump that convey biochemical messages between insulin and its target cells are disrupted. As a result, the big and plump insulin does not exert its normal or full effects. Put another way, the body is resistant to the effects of insulin. What does insulin normally do? Well, the pancreas secretes varying amounts of insulin during the day in response to food intake. Insulin works to maintain blood sugar (glucose) at normal levels. Thus, insulin prevents blood glucose from becoming too elevated. If insulin does not work in this way, high blood sugars and diabetes would occur.
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