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The fatty tissue in the liver may break up liver cells (steatonecrosis) and the patient may develop cirrhosis (scarring of the liver). Recent studies indicate that NASH can disease result in the development of fibrous tissue in the liver (fibrosis) in up to 40% of patients or cirrhosis disease in 5-10% of patients. It is not certain why some NASH patients will progress to this serious form of chronic liver disease while disease others do not. Studies report that the progression to fibrosis or cirrhosis for NASH patients is variable but can occasionally occur in less that 20 years.Some studies have shown that 20% to 40% of people who are grossly overweight will develop NASH. If a patient is grossly overweight, however, it does not mean that he/she will develop NASH. Many patients with NASH will show an increase of certain iron proteins (ferritin) in their blood, but whether this relates to any injury to the liver is unknown.How is NASH diagnosed?Many NASH patients are unaware of their conditions because they do not exhibit any symptoms.
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