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In the absence of any specific clinical or biochemical signs, NASH remains a diagnosis that is made after excluding other causes of fatty liver and other causes of elevated liver enzymes. The most frequent biochemical abnormality in the blood in NASH is persistent, poynard mild to moderately elevated transaminases (ALT poynard and AST). Transaminases poynard are the liver enzymes that are most often elevated in the various types of hepatitis. (Remember that hepatitis refers to inflammation of the liver.) In NASH, their levels tend to fluctuate from month to month, and most often the ALT is greater than the AST. This is different from alcoholic liver disease (ALD), in which the AST is usually greater than the ALT. Indeed, this fortuitous finding often leads to initially considering the diagnosis of NAFLD or NASH. Unfortunately, however, no biochemical test or imaging procedure can differentiate simple fatty liver from NASH.
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