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| variceal bleeding, chronic, plump moms , real plump , arteriosclerosis, plump furries , fats, choline deficiency, infected, girls with fat ass , fatty fat fat , plump white , rapid fulminant liver failure, | Cases occur most commonly in obese, middle-aged women with white girls with fat asses diabetes. However, NASH may also occur in children and normal-weight men with white girls with fat asses normal glucose and lipid metabolism. The pathophysiology involves two steps. The first is insulin resistance, which causes steatosis. The second is oxidative stress, which produces lipid peroxidation and activates inflammatory cytokines resulting in NASH. Liver biopsy provides prognostic information and identifies white girls with fat asses NASH patients who may benefit from therapy. Treatment consists of managing the comorbidities: obesity, diabetes, and hyperlipidemia. Although antioxidant therapy with vitamin E is often used, ursodeoxycholic acid is the only drug that has shown benefit and is the most promising of the drugs currently being investigated. |
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| to Text File Printer Clipboard E-mail Order All: 1 Review: 1 1: J Clin Gastroenterol. 2002 arteriosclerosis Mar;34(3):255-62. Links Update on nonalcoholic fatty liver disease.McCullough AJ.Division of Gastroenterology and the Robert Schwartz arteriosclerosis Center of Metabolism and Nutrition arteriosclerosis at MetroHealth Medical Center and Case Western Reserve University, Cleveland, Ohio 44109-1998, USA. ajm3@po.cwru.eduNonalcoholic fatty liver disease is now recognized as the most common liver disease in the United States, with a prevalence of approximately 5% in the general population and up to 25% to 75% in patients with obesity and type II diabetes mellitus. Nonalcoholic fatty liver disease is a clinicopathologic syndrome with a wide spectrum of histologic abnormalities and clinical outcomes. Hepatic steatosis has a benign clinical course. In contrast, nonalcoholic steatohepatitis (NASH) may progress to cirrhosis and liver-related death in 25% and 10% of patients, respectively. |
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